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This comprehensive immune response should be exploited in next-generation vaccines to complement antibodies in the global population, which is currently overwhelmingly seropositive against SARS-CoV-2 spike following vaccination and/or infection

(d) Physician considerations beginning January 1, 2026

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The form, dose, and timing are worth recording, and further workup becomes necessary if the elevation persists once those sources are accounted for, or if symptoms, examination findings, or other labs raise concern